Evaluating of Anti-Diabetic Potential and Beneficial Effect of Nutraceutical Powder in Management of Various Diabetic Complication

Abstract

Diabetes mellitus is a chronic disorder that generates raised more blood glucose levels due to insufficient insulin production or activity. This illness's metabolic imbalance raises the likelihood of long-term problems in blood vessels, resulting in frequent hospitalization and increased risk of cardiovascular disease. Providing appropriate treatment to diabetic patients is vital to avert complications. Female Wistar rats were divided into different groups (n = 6). Eight groups each one induced alloxan to type1 diabetes and treated with different doses of nutraceutical powder. 24 h after the last dose, animals were subjected to behavioural, biochemical, and histopathological evaluations. The data were analysed by one-way ANOVA. In in-vitro model of alpha amylase inhibition assay the absorbance of sample increased as the concentration of nutraceutical powder will increase. In alloxan induced in vivo diabetic model in Wistar rats the body weight, the water intake observed the increasing in disease control as comparing to normal, standard, Test drug group1 lower dose(200mg/kg) and Test drug group 2(500mg/kg), the food intake observed the decreasing in disease control as comparing to normal, standard, Test drug group1 lower dose(200mg/kg) and Test drug group 2(500mg/kg).After 45 days of study, all biochemical parameters the blood, LDL, insulin and creatinine level observed the increasing in disease control group with comparing to normal control, standard control and tests groups. The study will conclude our formulation has potential for managing diabetes by stimulating the regeneration of pancreatic β-cells and further research is needed to understand the active constituents and mechanism of action.